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another RP250 question, \"amp/mixer\" button

i understand what this button does and this is my dilemma....

my chain goes,

guitar --> RP250 --> VOX DA10 (amp) --> BOSS RC20 --> PA Head

my Vox amp serves more as a preamp since the speaker gets defeated by going \"line out\" to my PA Head. now, the Vox IS a modeling amp, i have it set to \"CLEAN 2\".

my questions....

does switching the RP250's \"amp/mixer\" output defeat or enable the amp and speaker models i've already saved to my presets? and even though i'm using a guitar amp, i AM sending it to a mixer.

so, how should i set the \"amp/mixer\" switch? does it REALLY matter?

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